Oxford Nanoimaging – Super Resolution Single Molecule Microscopes

Oxford Nanoimaging is a UK-based company that was established to commercialise the most advanced fluorescence microscopy methods for single molecule imaging. Their technology was developed over the last 8 years by Professor Achillefs Kapanidis and his research team at the University of Oxford and will be key to helping develop an understanding of cellular behaviour and diseases at the molecular level.

Profession Kapanidis is a world leader in the field of single molecule fluorescence for the better understanding of the manipulation of DNA and RNA. Based on his experience and expertise, they developed a bespoke platform that both simplifies and increases the efficiency of fluorescence imaging. This elegant design will help biological researchers streamline the development of novel assays and sensors.

Their first product, the Nanoimager is a compact benchtop super resolution microscope that can be installed in any laboratory. It can produce biological information that was not previously possible revealing vital information about the interactions and dynamics of single molecules.

The simple closed system utilises the latest technology components to ensure you get the highest resolution images. It negates the requirement for optical benches and includes vibration damping to help produce drift-free super-resolution images.

The Nanoimager also offers several imaging modes including epifluorescence, Total Internal Reflection Fluorescence (TIRF) and Highly Inclined and Laminated Optical Sheet (HILO) which are all capable of imaging at high temporal resolution enabling you to capture super resolution and smFRET images.

It has already been used for applications such as:

  • Quantitative Cellular Imaging
  • Molecular mechanisms and interactions
  • Protein complex assembly
  • Epigentic mapping
  • DNA paint
  • Single molecule imaging using Single Molecule Localisation
  • Single Molecule FRET
  • Exosomes and microvessicles
  • Neuronal imaging